眼の進化と生物多様性を研究しています。
The eye is one of the most elaborate organs in animals and the study of its evolution is of particular interest. It has been difficult to understand how this complex organ arose. Molluscs provide a good example of the application of evolutionary genomics, as all eye types have evolved in one lineage.
Tag: #Evolution #Eye #Molluscs #Research #Bioinfo #Papers #Photo #Movie #Link

 

Ortholog DB

Orthologyは遺伝子の進化を見る上で非常に重要な概念ですが、近年ゲノム解読生物が増えるにつれOrthologyの大規模解析をしたDataBaseがいくつかでてきています。As of 20 Feb. 2008

MANTiS

Algorithm: Reciprocal smallest distance algorithm

Genomes: ENSEMBL次第

Orthologous pairs: -

Raw data download: Available

Comments: DBというよりもJAVA appletを使ったバイオインフォマティクスツール。Gain/Lossなど簡単な進化解析も可能。高機能だが重い。

InparanoidMultiParanoid

Algorithm: Reciprocal smallest distance algorithm

Genomes: 35 genomes

Orthologous pairs: -

Raw data download: Available

Comments: 2種間のOrthology比較が見やすい。

RoundUp Orthology Database

Algorithm: Reciprocal smallest distance algorithm

Genomes: 220 genomes

Orthologous pairs: 183,935,606 orthologous pairs

Raw data download: Available

Comments: 信用できるのか?というほどゲノム数が多い。

OrthoMCL Database Home

Algorithm: Markov Clustering algorithm, Reciprocal smallest distance algorithm

Genomes: 55 genomes

Orthologous group: 70,388 orthologous pairs

Raw data download: Available

Comments: Inaranoidと同じくらいに信頼性が高いとされている。

おまけ

Assessing performance of orthology detection strategies applied to eukaryotic genomes.

Chen et al.

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000383